DREAM Is Involved in the Genesis of Inflammation-Induced Prolabour Mediators in Human Myometrial and Amnion Cells

P Goradia; R Lim; M Lappas

Journal article

DREAM Is Involved in the Genesis of Inflammation-Induced Prolabour Mediators in Human Myometrial and Amnion Cells

P Goradia, R Lim, M Lappas

Biomed Research International | HINDAWI LTD | Published : 2018

DOI: 10.1155/2018/8237087

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Abstract

Preterm birth is the primary cause of perinatal morbidity and mortality worldwide. Inflammation induces a cascade of events leading to preterm birth by activating nuclear factor-B (NF-B). In nongestational tissues, downstream regulatory element antagonist modulator (DREAM) regulates NF-B activity. Our aims were to analyse DREAM expression in myometrium and fetal membranes obtained at term and preterm and to determine the effect of DREAM inhibition on prolabour mediators in primary myometrial and amnion cells. DREAM mRNA expression was significantly higher in fetal membranes obtained after spontaneous labour compared to nonlabour and in amnion from women with histological preterm chorioamnion..

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University of Melbourne Researchers

Martha Lappas Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

Associate Professor Martha Lappas is supported by a Career Development Fellowship from the National Health and Medical Research Council (NHMRC; Grant no. 1047025) and a Research Fellowship from The University of Melbourne. Funding for this study was provided by the NHMRC (Grant no. 1058786), Norman Beischer Medical Research Foundation, The University of Melbourne, and the Mercy Research Foundation. The clinical research midwives, Genevieve Christophers, Gabrielle Pell, and Rachel Murdoch, are gratefully acknowledged for their assistance with sample collection. The Obstetrics and Midwifery staff of Mercy Hospital for Women are acknowledged for their cooperation, and gratitude is extended to the women who so generously joined this study.